{"title":"Advances in Cellular Immune Mechanisms of Atopic Dermatitis","authors":"Jianghui Li, Xiaoning Yan, Haoyuan Hu","doi":"10.38007/ijwm.2023.040210","DOIUrl":null,"url":null,"abstract":": Atopic dermatitis is a common chronic inflammatory skin disease with severe itching as the most obvious clinical symptom. Its immunological mechanism is very complex, involving the participation of multiple immune cells and their cytokines, chemokines, pro-inflammatory molecules and other immune cascades. At the same time, it is related to skin barrier destruction, decreased expression of antimicrobial peptides, and immune-nervous system crosstalk. This article mainly reviews the various cells, cytokines and their cascades in the immune-related pathogenesis of atopic dermatitis, in order to provide corresponding theoretical basis for the treatment of atopic dermatitis.","PeriodicalId":326778,"journal":{"name":"International Journal of World Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of World Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.38007/ijwm.2023.040210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
: Atopic dermatitis is a common chronic inflammatory skin disease with severe itching as the most obvious clinical symptom. Its immunological mechanism is very complex, involving the participation of multiple immune cells and their cytokines, chemokines, pro-inflammatory molecules and other immune cascades. At the same time, it is related to skin barrier destruction, decreased expression of antimicrobial peptides, and immune-nervous system crosstalk. This article mainly reviews the various cells, cytokines and their cascades in the immune-related pathogenesis of atopic dermatitis, in order to provide corresponding theoretical basis for the treatment of atopic dermatitis.
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