The L-NAME effects in acute experimental peritonitis

Abstract

The article presents the results of research to study the course of experimental peritonitis in rats under administration of non-selective NO-synthase inhibitor, Nώ-nitro-L-arginine methyl ester (L-NAME). It has been shown that administration of L-NAME results in increase in the severity of in-toxication, reaction of leukocytes of blood and peritoneal exudate with inhibi-tion of phagocytic activity of neutrophils, enhance of oxidative stress, damage to the endothelium of blood vessels and peritoneum. „