A comparative study on the thermoregulatory effects of prazosin, dihydrobenzperidol and nifedipin on 2,4-dinitrophenol induced hyperthermia in rabbits.
{"title":"A comparative study on the thermoregulatory effects of prazosin, dihydrobenzperidol and nifedipin on 2,4-dinitrophenol induced hyperthermia in rabbits.","authors":"Z Szreder, I Gagało","doi":"10.1016/0306-3623(91)90591-s","DOIUrl":null,"url":null,"abstract":"<p><p>1. Thermal responses to prazosin (PRA) and dihydrobenzperidol (DHBP) (0.75 mg/kg) or nifedipin (ADA: 0.05 mg/kg) administered intravenously were investigated in hyperthermic rabbits. 2. Hyperthermia produced by dinitrophenol (DNP; 20 mg/kg; i.v.), resulted from stimulation of the metabolic rate. 3. All the investigated drugs; i.e. PRA, DHBP, ADA reduced the hyperthermic activity of DNP. Contrary to DHBP and ADA, PRA did not change DNP--stimulated metabolism. 4. Possible mechanisms responsible for prazosin antihyperthermizing action are discussed.</p>","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1139-42"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90591-s","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0306-3623(91)90591-s","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
1. Thermal responses to prazosin (PRA) and dihydrobenzperidol (DHBP) (0.75 mg/kg) or nifedipin (ADA: 0.05 mg/kg) administered intravenously were investigated in hyperthermic rabbits. 2. Hyperthermia produced by dinitrophenol (DNP; 20 mg/kg; i.v.), resulted from stimulation of the metabolic rate. 3. All the investigated drugs; i.e. PRA, DHBP, ADA reduced the hyperthermic activity of DNP. Contrary to DHBP and ADA, PRA did not change DNP--stimulated metabolism. 4. Possible mechanisms responsible for prazosin antihyperthermizing action are discussed.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
