INHIBITORY EFFECT OF CARBOHYDRAZ ON SECRETORY ACTIVITY OF THE PANCREAS

Abstract

Since the time of Ivan Petrovich Pavlov's work, it is known that the juice collected from the pancreatic fistula, when it is re-introduced into the duodenum, inhibits the secretion of the pancreas. Most recently, in the works of American, French and Japanese physiologists, this inhibition was associated with the fact that trypsinogen secreted in the pancreatic secretion and trypsin contained in the duodenal contents inhibit the release of the hormone cholicystokininpancreosimin by duodenal endocrine cells - a powerful stimulator of enzyme secretion by the pancreas. This explanation of the reverse reproduction of pancreatic secretion from the duodenum is recognized by most experts. In connection with the above, the study of this problem seems to be an urgent task.