TRAIL Single Nucleotide Polymorphism in Type 2 Egyptian Diabetic Patients

Abstract

Objective: The research attempted to assess the susceptibility of TRAIL polymorphism (rs1131580) in T2DM and its relationship with metabolic parameters in T2DM. Patients and Methods: This study was performed on 80 subjects, 60 T2DM patients and age & sex matched 20 healthy volunteers as controls, The patients had complete clinical examination and detailed history collection, and detection of TRAIL single nucleotide polymorphism rs1131580 by PCR-RFLP standing for polymerase chain reaction-restriction fragment length polymorphism.. Results: TRAIL SNP rs1131580 mutation was greatly more common in the group of diabetics. Conclusion: A homozygous variant allele (CC) genotype of the TRAIL SNP rs1131580 carries a 1.5-fold risk of DM. Also, having the C allele elevated the risk of T2DM by 1.7 times.