Pyoderma gangrenosum in a patient with Down syndrome

Abstract

Pyoderma gangrenosum (PG) is a rare, potentially fatal skin disease with the formation of a painful, rapidly progressing (dynamic) necrotic ulcer with undermined blue-violet margins. PG in 50-70% of patients coexists with other systemic diseases: inflammatory bowel diseases (most frequent), arthritis (most often rheumatoid arthritis – RA), cancer of internal organs, myeloproliferative syndromes