STUDY OF THE DYNAMICS OF REPRODUCTION OF M. LEPRAE UNDER THE CONDITIONS OF APPLICATION OF ANISEED LOFANT EXTRACT OBTAINED FROM SUPERCRITICAL FLUID EXTRACTION METHOD

Yurtaeva E.A., Luzhnova S.A., Tyrkov A.G.
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Abstract

One of the ways to solve the problem of drug resistance in the therapy of infectious diseases is to develop herbal preparations with high antibacterial activity, which have a good drug safety profile, is extremely significant for long-term therapy, the use of which could complement and improve the used combination therapy regimens. The aim of our study was to study the anti-leprosy activity of lofant anise extract obtained by supercritical fluid extraction using CO2 containing phenolic compounds such as gallic acid, coumarin, umbelliferon, luteolin, quercetin, taxifolin, rutin. Materials and methods. The anti-leprosy activity had been studied on Shepard's model. Blood parameters were examined on a SYSMEX XT – 2000i hematological analyzer (Japan). Conclusion. Lofant anise extract, obtained by supercritical fluid extraction using CO2, has a bacteriostatic effect on M. leprae, which is not only comparable to the effect of dapsone, but also with a more prolonged course exceeding it. Unlike the drug of choice (dapsone), the extract, when administered for 30 days, does not cause changes in red blood parameters and does not cause neutropenia. The identified effects actualize further research of the extract for the development of dosage forms based on it for practical health care.
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应用超临界流体萃取法提取的大料莲叶提取物,研究麻风分枝杆菌的繁殖动态
开发抗菌活性高、药物安全性好、对长期治疗具有重要意义的中药制剂是解决传染病治疗中耐药问题的途径之一,其使用可以补充和改进现有的联合治疗方案。本实验研究了CO2超临界萃取法提取的大茴香提取物中未食子酸、香豆素、伞形花、木犀草素、槲皮素、紫杉素、芦丁等酚类化合物的抗麻风病活性。材料和方法。用Shepard模型研究了其抗麻风病活性。血液参数检测采用SYSMEX XT - 2000i血液分析仪(日本)。结论。用CO2超临界流体萃取得到的香茴香提取物对麻风杆菌的抑菌作用不仅与氨苯砜相当,而且作用时间比氨苯砜更长。与选择的药物(氨苯砜)不同,当服用30天时,提取物不会引起红细胞参数的变化,也不会引起中性粒细胞减少症。确定的效果实现了提取物的进一步研究,以开发用于实际保健的剂型为基础。
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