[The action of benzimidazole derivative preparations on the formation of DNA-protein cross-links in the UV irradiation of chromatin].

E M Mil', V I Biniukov, V M Zhil'tsova, L G Stoliarova, Iu V Kuznetsov
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Abstract

Effect of benzimidazole-derivatives on the DNA-protein binding formation was studied after UV-radiation of chromatin. These derivatives were shown to protect chromatin from UV-induced DNA-protein binding formation. Structural analog contained two aminomethyl residuals sensibilized additional binding formation in chromatin. Results suggested, that benzimidazole interacted with DNA, while aminomethyl groups interacted with protein and sensibilized binding of DNA with histone H1.

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[苯并咪唑衍生物对紫外照射染色质中dna -蛋白交联形成的作用]。
研究了苯并咪唑衍生物在染色质紫外线照射后对dna -蛋白结合形成的影响。这些衍生物被证明可以保护染色质免受紫外线诱导的dna -蛋白质结合形成。结构类似物含有两个氨基甲基残基,可在染色质中敏化额外的结合形成。结果表明,苯并咪唑与DNA相互作用,而氨基甲基与蛋白质相互作用并使DNA与组蛋白H1的结合变得敏感。
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