Dynamic optical coherence elastography and applications

Xing Liang, S. Boppart
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引用次数: 1

Abstract

A novel, dynamic, non-invasive, high-speed dynamic optical coherence elastography (OCE) system has been developed for quantitatively mapping tissue biomechanical properties utilizing spectral-domain optical coherence tomography (OCT) and a mechanical wave driver. This dynamic OCE technique is based on solving wave equations without speckle tracking algorithms. Using phase-resolved imaging, we demonstrate OCE can map dynamic elastic moduli of normal and neoplastic ex vivo human breast tissue. This dynamic OCE technique is used to determine in vivo skin biomechanical properties based on mechanical surface wave propagation. Quantitative Young's moduli are measured on human skin from different sites, orientations, and frequencies.
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动态光学相干弹性成像及其应用
一种新型的、动态的、无创的、高速的动态光学相干弹性成像(OCE)系统被开发出来,用于利用光谱域光学相干断层扫描(OCT)和机械波驱动器定量绘制组织生物力学特性。这种动态OCE技术是基于求解波动方程而不需要散斑跟踪算法。通过相位分辨成像,我们证明OCE可以绘制正常和肿瘤离体人乳腺组织的动态弹性模量。这种动态OCE技术被用于基于机械表面波传播来确定体内皮肤的生物力学特性。定量杨氏模量是在人体皮肤上从不同部位、方向和频率测量的。
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