Chenyang He, Alexander Tarr, Paddy Tighe, S. Korposh, S. Morgan
{"title":"Peptide Functionalized Long Period Grating Optical Fibre Sensor for Antibody Measurement with Microfluidic System","authors":"Chenyang He, Alexander Tarr, Paddy Tighe, S. Korposh, S. Morgan","doi":"10.1109/CSNDSP54353.2022.9907987","DOIUrl":null,"url":null,"abstract":"A long period grating (LPG) optical fibre sensor modified coated with an Immunoglobulin G (IgG)-binding peptide is reported. The IgG-binding peptide provides a controllable binding affinity towards IgG which is comparable to antibody-antigen interaction due to the non-covalent bonds of the peptide’s amino acid enabling development of a reversible optical fibre immunosensor. A microfluidic system has been developed for reliable flow of liquid over the sensor.","PeriodicalId":288069,"journal":{"name":"2022 13th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP)","volume":"9 4","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2022 13th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/CSNDSP54353.2022.9907987","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
A long period grating (LPG) optical fibre sensor modified coated with an Immunoglobulin G (IgG)-binding peptide is reported. The IgG-binding peptide provides a controllable binding affinity towards IgG which is comparable to antibody-antigen interaction due to the non-covalent bonds of the peptide’s amino acid enabling development of a reversible optical fibre immunosensor. A microfluidic system has been developed for reliable flow of liquid over the sensor.
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