[Clinical and pathological study of dysplasia, early invasive carcinoma and invasive carcinoma (the invasion 5mm deep) in oral cavity].

Abstract

This study was carried out to clarify the clinico-pathological conditions of dysplasia, early carcinoma and invasive carcinoma (the invasion 5mm deep) in oral cavity. 57 cases (61 lesions), Which were resected by surgery alone, and diagnosed histologically as dysplasia, early invasive carcinoma and invasive carcinoma (the invasion 5mm deep), were used. All lesions were serially sectioned, and the relationship between clinical and histological appearances were examined. Further, a disease map was made in order to examine the distribution of carcinoma. Age of patients with an early carcinoma showed a wide distribution. Sex were 33 males and 24 females. Twenty-two cases of dysplasia showed white, red, red and white patch, and papillary outgrowth. Twenty-three cases of early invasive carcinoma showed same appearance as those of dysplasia. Sixteen cases of 5mm depth invasive carcinoma showed white, red, white and red patch, and granular and ulcerous appearance. In red lesions, so-called atypical vessels were seen. Atypical vessels were recognized as punctation. The punctation in area of dysplasia and carcinoma in situ were regular in shape. On the other hand, the punctation in 5mm deep invasive carcinoma became irregular in size and orientation. There was no correlation between the size and level of invasion. Fixed survival was 95.5% in early invasive carcinoma, 92.9% in 5mm deep invasive carcinoma. There were two types of distribution patterns of early invasive and 3mm deep invasive carcinoma; multi-centric and mono-centric pattern. All of 5mm deep invasive carcinoma showed mono-centric pattern, but the outline of carcinomatous area was more complicated in shape.