Possibilities and prospects of the application of the in vivo and in vitro toxic cuprizone model for demyelination in experimental and clinical neurology (literature review and own research results)

Abstract

In this article, literature data and research findings obtained from the Experimental modeling laboratory of Institute of Genetic and Regenerative medicine are shown. This review testifies the effectiveness of using the in vivo and in vitro toxic cuprizone model for demyelination with the purpose of studying the pathogenic factors which include the immune, endocrine and oxidative stress factors associated with age, sex and strains of animals, as well as finding remyelinizing/neuroprotective remedies. The advantages of the cuprizone model for demyelination over other experimental models are also described. Using, as an example the effectiveness of our application of cytokines (leukemia inhibitory factor) and hormones (melatonin) with the remyelinating effects we show the promise of the in vitro demyelination cuprizone model for screening the remyelinating factors. The possibilities of using the experimental cuprizone model for studying other pathologies of the nervous system are justified.