Study of the Effect of Nonselective Organic Solvent Nature on the Self-Organization of Amphiphilic Block Copolymers of D,L-Lactide and Ethylene Oxide in Aqueous Solution
E. V. Kuznetsova, E. M. Shirokova, Yu. A. Puchkova, E. V. Yastremsky, S. N. Chvalun
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引用次数: 0
Abstract
The self-organization of biocompatible amphiphilic block copolymers of D,L-lactide and ethylene oxide with various hydrophobic poly(D,L-lactide) block length in aqueous media has been investigated. It has been shown that the nature of nonselective organic solvent has a considerable effect on the size, size polydispersity, and morphology of micelles of a block copolymer with a long poly(D,L-lactide) block. To elucidate the dependence of properties of block copolymer micelles on the common organic solvent type (acetone, tetrahydrofuran, N,N-dimethylformamide, and acetonitrile) various parameters of the used solvents have been estimated, and correlation between the Flory–Huggins coefficient and the surface tension between the hydrophobic block and the nonselective organic solvent and the parameters of micellar structures has been found.
研究了具有不同疏水聚(D, l -丙交酯)嵌段长度的生物相容性D, l -丙交酯和环氧乙烷两亲共聚物在水介质中的自组织。研究表明，非选择性有机溶剂的性质对长聚(D, l -丙交酯)嵌段共聚物的尺寸、尺寸多分散性和胶束形态有相当大的影响。为了阐明嵌段共聚物胶束性质与常用有机溶剂类型(丙酮、四氢呋喃、N、N-二甲基甲酰胺和乙腈)的关系，我们估计了所用溶剂的各种参数，并发现了疏水嵌段与非选择性有机溶剂之间的弗洛里-哈金斯系数和表面张力与胶束结构参数之间的相关性。
期刊介绍：
Polymer Science, Series C (Selected Topics) is a journal published in collaboration with the Russian Academy of Sciences. Series C (Selected Topics) includes experimental and theoretical papers and reviews on the selected actual topics of macromolecular science chosen by the editorial board (1 issue a year). Submission is possible by invitation only. All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed
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