Association of plasma vitamin A level with type 2 diabetes mellitus: a community aging population-based cross-sectional study

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Science and Human Wellness Pub Date : 2024-05-27 DOI:10.26599/FSHW.2022.9250173

Pengfei Li , Jingjing Xu , Yujie Guo , Xiaojun Ma , Shaobo Zhou , Chi Zhang , Huiyan Yu , Ying Wang , Xixiang Wang , Linhong Yuan

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Abstract

Recent studies indicated that vitamin A (VA) might be involved in the pathology of type 2 diabetes mellitus (T2DM). This cross-sectional study was conducted to explore the association between circulating VA level and T2DM. A total of 1 818 subjects aged 50 years old and above were recruited from the community. Binomial logistic regression and restricted cubic spline (RCS) were applied to analyze the association of plasma VA level with the risk of T2DM. Serum VA and lipid-adjusted VA levels of T2DM patients were significantly higher than that of non-T2DM subjects (P < 0.05). The ratios of plasma VA/total cholesterol (TC), VA/high-density lipoprotein cholesterol (HDL-c) and VA/low-density lipoprotein cholesterol (LDL-c) were positively associated with the risk of T2DM in the aging population (P < 0.05). Compared with the Q1 level, subjects with Q2 to Q3 levels of plasma VA/triglyceride (TG) have decreased risk of T2DM (odds ratio (OR)_Q2 = 0.68, P_Q2 = 0.021; OR_Q3 = 0.59, P_Q3 < 0.01). Our results indicated that the imbalance of circulating lipids and VA might affect the relationship between VA and T2DM. The middle and aging subjects with higher ratios of plasma VA/TC, VA/HDL-c, and VA/LDL-c displayed increased risk for T2DM, but the moderate ratio of VA/TG might protect against risk of T2DM.

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血浆维生素 A 水平与 2 型糖尿病的关系：一项基于社区老龄人口的横断面研究

最近的研究表明，维生素 A（VA）可能与 2 型糖尿病（T2DM）的病理过程有关。本横断面研究旨在探讨循环中维生素 A 水平与 T2DM 之间的关系。研究从社区招募了 1 818 名 50 岁及以上的受试者。应用二项式逻辑回归和限制性立方样条（RCS）分析血浆 VA 水平与 T2DM 风险的关系。T2DM 患者的血清 VA 和血脂调整后的 VA 水平明显高于非 T2DM 受试者（P < 0.05）。血浆 VA/总胆固醇（TC）、VA/高密度脂蛋白胆固醇（HDL-c）和 VA/低密度脂蛋白胆固醇（LDL-c）之比与老龄人群罹患 T2DM 的风险呈正相关（P < 0.05）。与 Q1 水平相比，血浆 VA/甘油三酯（TG）处于 Q2 至 Q3 水平的受试者罹患 T2DM 的风险降低（几率比（OR）Q2 = 0.68，PQ2 = 0.021；ORQ3 = 0.59，PQ3 <0.01）。我们的研究结果表明，循环血脂和 VA 的不平衡可能会影响 VA 与 T2DM 的关系。血浆 VA/TC、VA/HDL-c 和 VA/LDL-c 比率较高的中老年受试者患 T2DM 的风险增加，但 VA/TG 比率适中的受试者可能会降低患 T2DM 的风险。

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来源期刊

Food Science and Human Wellness Agricultural and Biological Sciences-Food Science

CiteScore

8.30

自引率

5.70%

发文量

审稿时长

28 days

期刊介绍： Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.