The variation of the androgen receptor single nucleotide polymorphism (rs6152) gene in different stages of endometriosis disease in Iraqi women

Abstract

Gene (AR) is a nuclear receptor belonging to a family of super-nuclear futures. This study aims to screen the diagnostic and clinical of the (AR) gene single nucleotide polymorphism (rs6152) at various stages of endometriosis. Methods: 120 serums of Iraqi women suffering from endometriosis were taken and it was distinguished into (I, II, III, and IV) stages according to the “American Society of Reproductive Medicine” (ASRM) guidelines. Iraqi healthy women numbering 50 were taken as a control group. The statistical software (SPSS. 2017) Version (25.0) were used to analyze the data. Results: The (AR) gene single nucleotide polymorphism (rs6152) has three genotypes which are (AA, GA, and GG), 72% of the group in the control carry the (GA) genotype copy of the (AR) gene. The wild-type (GG) genotype was found in (85) patient cohort with a genotype frequency of (70.8%), while the mutant genotype (AA) was detected in 17 (14.2%), and (GA) was noticed in 18 patients with a genotype frequency (15.0%). Conclusion: The augmentation of frequency of the (GG) genotype of this SNP in different stages of endometriosis can be considered promising signs to identify and diagnose patients with endometriosis. Abbreviations: AR = androgen receptor, kDa = kilodaltons, DNA = Deoxyribonucleic acid, SNP= Single nucleotide polymorphism, bp = base pair.