Uncovering the Mechanism of Fuzi and Baishao in Treating Rheumatoid Arthritis Using Systems Pharmacology and Molecular Docking

Yuxi Zhang, Haoming Zhou, Juan Liu, Dandan Zhang, Shijun Yue, Cheng Peng
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Abstract

Background and ObjectivesTraditional Chinese Medicine has been implemented in clinical practice for thousands of years to treat rheumatoid arthritis (RA). Aconitum carmichaelii Debx (Fuzi) and Paeonia lactiflora Pall (Baishao) are a common herb-pair that is used in many herbal prescriptions to treat RA. However, the mechanism of Fuzi and Baishao for treating RA remains unclear. Here, we used a systems pharmacology and molecular docking approach to investigate the mechanism of Fuzi and Baishao in the treatment of RA.
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从系统药理学和分子对接研究附子、百芍治疗类风湿关节炎的作用机制
背景与目的中医治疗类风湿关节炎(RA)已在临床实践中实施了数千年。附子乌头和白芍是治疗类风湿性关节炎的常用中药对。然而,附子、百芍治疗类风湿性关节炎的作用机制尚不清楚。本研究采用系统药理学和分子对接的方法,探讨附子、百芍治疗类风湿性关节炎的作用机制。
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