Synthesis, In Vitro and In Silico Biological Studies of 1, 2, 3-Triazole-Furan Chalcone Hybrids

Abstract

In the present investigation, we focused our interest to develop 1, 2, 3-triazolefuran chalcone hybrids along with their biological profile. The synthesis of target molecules involves sequence of reactions, namely diazotization, nucleophilic substitution, cycloaddition and finally, solvent-free Claisen–Schmidt condensation reaction. The biological profile of the synthesized compounds was carried out using prediction of activity spectra for substances and results revealed that the synthesized compounds may act as mild antimicrobial agents.