Emerging Mueller matrix microscopy applications in biophysics and biomedicine

IF 5.9 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Rivista Del Nuovo Cimento Pub Date : 2023-08-01 DOI:10.1007/s40766-023-00046-5
Alberto Diaspro, Paolo Bianchini, Fabio Callegari, Lisa Cuneo, Riccardo Marongiu, Aymeric Le Gratiet, Ali Mohebi, M. Scotto, Colin J. R. Sheppard
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Abstract

Abstract Polarized and wide-field light microscopy has been studied for many years to develop accurate and information-rich images within a focused framework on biophysics and biomedicine. Technological advances and conceptual understanding have recently led to significant results in terms of applications. Simultaneously, developments in label-free methods are opening a new window on molecular imaging at a low dose of illumination. The ability to encode and decode polarized light pixel by pixel, coupled with the computational strength provided by artificial intelligence, is the running perspective of label-free optical microscopy. More specifically, the information-rich content Mueller matrix microscopy through its 16 elements offers multimodal imaging, an original data set to be integrated with other advanced optical methods. This dilates the spectrum of possible and potential applications. Here, we explore the recent advances in basic and applied research towards technological applications tailored for specific questions in biophysics and biomedicine.

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新兴的米勒矩阵显微镜在生物物理学和生物医学中的应用
偏振和宽视场光显微镜已经研究了多年,以在生物物理学和生物医学的重点框架内开发准确和信息丰富的图像。技术进步和概念理解最近在应用方面取得了重大成果。同时,无标记方法的发展为低剂量光照下的分子成像打开了一扇新的窗口。逐像素编码和解码偏振光的能力,加上人工智能提供的计算能力,是无标签光学显微镜的运行前景。更具体地说,信息丰富的内容穆勒矩阵显微镜通过其16个元素提供多模态成像,原始数据集与其他先进的光学方法集成。这扩大了可能和潜在应用的范围。在这里,我们探讨了针对生物物理学和生物医学中特定问题的技术应用的基础和应用研究的最新进展。
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来源期刊
Rivista Del Nuovo Cimento
Rivista Del Nuovo Cimento 物理-物理:综合
CiteScore
9.50
自引率
2.20%
发文量
11
审稿时长
>12 weeks
期刊介绍: La Rivista del Nuovo Cimento is an international peer-reviewed journal. It publishes monographs in all fields of physics. These monographies aim at presenting the state of the art of topical subjects of relevant interest for the community. Usually, authors are invited and topics suggested by the Deputy Editors-in-Chief, but also spontaneous submissions are examined.
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