Retinal and Choroidal Alterations in Migraine Patients Compared to Normal Healthy Controls

Miriam L. Conway, Irene Ctori
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Abstract

Purpose: Migraine is an incapacitating neurovascular disorder that primarily affects the working-age population. Researchers have postulated that the transient vascular alterations during each migraine attack lead to ischemic damage in the eye which can be measured via optical coherence tomography. Methods: We recruited 29 volunteers: 13 migraineurs (mean age 28 ± 8.8 years; 12 female and 1 male) and 16 age-matched controls (mean age 26.6 ± 6.9; 9 female and 7 male). All individuals underwent a detailed ophthalmic examination by a qualified optometrist and a Migraine Disability Assessment. The investigators were blind to the migraine diagnosis. Retinal Nerve Fiber Layer (RNFL) thickness, Retinal Thickness (RT), Ganglion Cell Complex (GCL), ranging from the inner-limiting membrane to the inner plexiform layer, and Choroidal Thickness (CT) were measured using the 3D OCT-1Maestro, Topcon, a Spectral Domain OCT (SD-OCT) device. Results: In the migraine population average RNFL was lower for several parameters. However, results did not reach statistical significance. A significant decrease in the right eye inferior parafoveal ganglion cell layer in the migraine group of patients (mean = 25.15, SD = 4.08) compared to normal healthy controls (mean = 28.81, SD = 4.85; t = (27) = 2.17, p = 0.039) was documented. No other ganglion cell layer or choroidal thickness reached significance. No significant relationship between ocular thickness parameters and MIDAS score, parameters and either MIDAS score or frequency of headaches was found. Conclusion: A significant decrease in the right inferior parafoveal ganglion cell layer for migraine patients was reported. All other parameters did not reach significance.
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偏头痛患者与正常健康对照的视网膜和脉络膜改变
目的:偏头痛是一种主要影响工作年龄人群的失能性神经血管疾病。研究人员假设,每次偏头痛发作时短暂的血管改变会导致眼睛的缺血性损伤,这可以通过光学相干断层扫描来测量。方法:招募29名志愿者:偏头痛患者13例(平均年龄28±8.8岁;12名女性和1名男性)和16名年龄匹配的对照组(平均年龄26.6±6.9;9名女性和7名男性)。所有人都接受了由合格验光师进行的详细眼科检查和偏头痛残疾评估。研究人员对偏头痛的诊断一无所知。使用3D OCT- 1maestro, Topcon,一种光谱域OCT (SD-OCT)设备测量视网膜神经纤维层(RNFL)厚度,视网膜厚度(RT),神经节细胞复合体(GCL),范围从内限制膜到内丛状层,脉络膜厚度(CT)。结果:在偏头痛人群中,几个参数的平均RNFL较低。然而,结果没有达到统计学意义。偏头痛组患者右眼下中央凹旁神经节细胞层(mean = 25.15, SD = 4.08)较正常健康对照组(mean = 28.81, SD = 4.85;T = (27) = 2.17, p = 0.039)。其他神经节细胞层及脉络膜厚度未见明显变化。眼厚参数与MIDAS评分、参数与MIDAS评分或头痛频率均无显著关系。结论:偏头痛患者右下中央凹旁神经节细胞层明显减少。其他参数均无显著意义。
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