Relationship between Whole Body Iodine-131 Effective Half-Life and Estimated Glomerular Filtration Rate for Papillary Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

Asim Abualnaja, Hanaa Alsheikh, Khaled Soliman, Meshal Alnefaie, Abdulraheem Alsheri
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Abstract

Background: The aim of this work was to examine the relationship between the estimated glomerular filtration rate (eGFR) as indicator of renal efficiency potentially related to the ability to release radioactive iodine from the patients bodies and the radioactive iodine whole body effective half-life (WBEHL) defined as the time taken for the administered activity to decay to half of its value for papillary thyroid cancer (PTC) patients undergoing radioactive iodine therapy (RAIT) in a tertiary care medical Centre. Methods: This retrospective observational study included seventy nine patients, sixty females and nineteen males. The patients were divided in two subgroups, those who have WBEHL of less than 11 hours (n = 51) and those with more than 11 (n = 28) hrs based on k-means clustering technique. Results: Analysis of variance (ANOVA) was used to find out if there is a statistically significant difference between the two subgroups Conclusion: There was not a statistically significant difference between the short and the longer WBEHL patients’ groups analyzed in this study.
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放射性碘治疗甲状腺乳头状癌患者全身碘-131有效半衰期与肾小球滤过率的关系
背景:这项工作的目的是研究估计的肾小球滤过率(eGFR)作为肾脏效率的指标(可能与从患者体内释放放射性碘的能力有关)与放射性碘全身有效半衰期(whbehl)之间的关系,whbehl定义为在三级保健医疗中接受放射性碘治疗(RAIT)的乳头状甲状腺癌(PTC)患者给予的活性衰减到其值的一半所需的时间中心。方法:回顾性观察研究纳入79例患者,其中女性60例,男性19例。基于k-means聚类技术将患者分为两组,分别为whbehl时间小于11小时(n = 51)和大于11小时(n = 28)。结果:采用方差分析(ANOVA)分析两亚组间是否存在统计学差异。结论:本研究分析的WBEHL短、长患者组间差异无统计学意义。
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