Investigation of antidiabetic effect of Ferula assa-foetida oleo gum resin and its essential oil on ovariectomised diabetic rats

IF 0.7 Q4 PLANT SCIENCES Indian Journal of Natural Products and Resources Pub Date : 2023-01-01 DOI:10.56042/ijnpr.v14i3.4627

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Abstract

The aim of the present study was to evaluate the hypoglycemic activity of asafoetida and essential oil of asafoetida (EOA) in ovariectomised (OVX) diabetic rats. Twenty-four female rats were divided into four groups consisting of 6 rats in each group. OVX Control, OVX diabetic, OVX diabetic and asafoetida (25 mg/kg), OVX diabetic and EOA 25 μL/kg. Fasting Blood glucose, lipid profiles and liver indices were measured, and liver and kidney histopathology was investigated. Urine volume, urea, creatinine, and microalbumin were measured. The neuropathic damage was assessed by the hot plate method. The results showed that only in the asafoetida group the blood sugar, ALT and AST levels decreased significantly. Consumption of food, water, and body weight also decreased in the asafoetida grouponly. Also, regarding histology, relative improvement was observed in kidney and liver tissue in the asafoetida group. A significant decrease in urine volume and improvement in creatinine, urea and microalbumin concentrations, as well as improvement in hot plate test response time, were observed in both treatment groups. It can be concluded that asafoetida is effective in treating diabetes, but its essential oil has no effective activity on diabetes mellitus.

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阿魏油胶树脂及其精油对去卵巢糖尿病大鼠的降糖作用研究

本研究的目的是评价荷叶花和荷叶花精油(EOA)对去卵巢(OVX)糖尿病大鼠的降糖活性。雌性大鼠24只，分为4组，每组6只。OVX对照、OVX糖尿病、OVX糖尿病加牛油果(25 mg/kg)、OVX糖尿病加EOA 25 μL/kg。测定空腹血糖、血脂及肝脏指标，观察肝肾组织病理学。测量尿量、尿素、肌酐和微量白蛋白。热板法评估神经病变损伤。结果显示，只有芦笋组血糖、谷丙转氨酶和谷丙转氨酶水平显著降低。食物、水和体重的消耗也仅在无尾豆科动物组有所下降。此外，在组织学方面，在肾和肝组织中观察到相对改善。在两个治疗组中，尿量显著减少，肌酐、尿素和微量白蛋白浓度显著改善，热板试验反应时间显著改善。由此可见，牛油果对糖尿病有治疗作用，但其挥发油对糖尿病无治疗作用。

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来源期刊

Indian Journal of Natural Products and Resources PLANT SCIENCES-

CiteScore

1.00

自引率

12.50%

发文量

审稿时长

52 weeks

期刊介绍： Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.