Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies

IF 2.5 4区医学 Q4 MATERIALS SCIENCE, BIOMATERIALS International Journal of Polymeric Materials and Polymeric Biomaterials Pub Date : 2023-09-29 DOI:10.1080/00914037.2023.2263133

Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao

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Abstract

AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).

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基于生物可降解聚合物的纳米药物递送系统用于妇科恶性肿瘤的治疗

摘要妇科恶性肿瘤是严重危害妇女生命健康的主要因素。化疗是治疗妇科恶性肿瘤的传统方法之一。医学上使用的常规化疗药物存在靶组织特异性分布差、毒副作用大等缺点。易出现肿瘤复发、侵袭、转移、耐药等问题。纳米给药系统的快速发展实现了衰减、增强、抑制转移、耐药等功能，为妇科恶性肿瘤的治疗带来了希望。本文就基于生物可降解聚合物的新型纳米给药系统及其对妇科肿瘤的介导治疗策略进行综述，以期为妇科恶性肿瘤纳米给药系统的开发和临床转化提供理论依据。项目资助:辽宁省自然科学基金(2020-ZLLH-41)资助。

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来源期刊

International Journal of Polymeric Materials and Polymeric Biomaterials Chemical Engineering-General Chemical Engineering

CiteScore

8.00

自引率

3.10%

发文量

审稿时长

3.3 months

期刊介绍： International Journal of Polymeric Materials and Polymeric Biomaterials is the official publication of the International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB). This journal provides a forum for the publication of peer-reviewed, English language articles and select reviews on all aspects of polymeric materials and biomedical polymers. Being interdisciplinary in nature, this journal publishes extensive contributions in the areas of encapsulation and controlled release technologies to address innovation needs as well.