Effect of Tiaoxie Yizhi Formula combined with atomoxetine and biofeedback therapy of school-age children with attention deficit hyperactivity disorder

IF 0.6 4区 医学 Q4 PHARMACOLOGY & PHARMACY Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI:10.4314/tjpr.v22i9.23
Wanyan Yao, Jing Cai, Guanjun Liang, Mingding Li, Min Su
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Abstract

Purpose: To investigate the effect of Tiaoxie Yizhi Formula combined with atomoxetine and biofeedback therapy on the Swanson, Nolan, and Pelham-IV Rating Scale (SNAP-IV) score as well as Clinical Global Impression (CGI) score of school-age children with attention deficit hyperactivity disorder (ADHD).Methods: Clinical data of 85 school-age children with ADHD who were admitted to Dushu Lake Hospital from April 2019 to June 2022 were analyzed retrospectively. Patients treated with biofeedback therapy and atomoxetine for 1 month were defined as control group (n = 42), while those treated with Tiaoxie Yizhi Formula in addition to what was given control group were defined as study group (n = 43). Efficacy, Traditional Chinese Medicine (TCM) symptom scores, SNAP-IV score, CGI score and cerebral electrophysiological indices were compared between the groups. The scores of the main and secondary syndromes were also compared between two groups.Results: Treatment response rate in study group was significantly higher than in control group (p < 0.05). There was no significant difference in scores of the main syndromes and secondary syndromes, SNAP-IV score or CGI score between the two groups before treatment (p > 0.05). However, scores of the two groups decreased significantly after treatment, and study group had significantly lower scores than control group (p < 0.05). There was no significant difference in sensorimotor rhythms (SMR) waves, β waves, or θ waves between the two groups before and after treatment (p > 0.05).Conclusion: Tiaoxie Yizhi Formula plus atomoxetine plus biofeedback therapy improves ADHDsymptoms more tha n biofeedback therapy and atomoxetine combination as shown by the reduction in TCM, SNAP-IV and CGI scores. However, investigations will need to be carried out using a larger sample size in order to validate these findings.
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调泻益智方联合托莫西汀及生物反馈治疗学龄期儿童注意缺陷多动障碍的疗效
目的:探讨调泻益智方联合托莫西汀及生物反馈疗法对学龄期注意缺陷多动障碍(ADHD)儿童Swanson, Nolan, and Pelham-IV评定量表(SNAP-IV)评分及临床整体印象(CGI)评分的影响。方法:回顾性分析2019年4月至2022年6月独墅湖医院收治的85例学龄期ADHD患儿的临床资料。以生物反馈疗法加托莫西汀治疗1个月的患者为对照组(n = 42),在给予对照组的基础上加用调泻益智方治疗的患者为研究组(n = 43)。比较两组疗效、中医症状评分、SNAP-IV评分、CGI评分及脑电生理指标。比较两组患者主次证候评分。结果:研究组治疗有效率显著高于对照组(p <0.05)。两组治疗前主、次证候评分、SNAP-IV评分、CGI评分比较,差异均无统计学意义(p >0.05)。但两组治疗后得分均显著下降,且研究组得分显著低于对照组(p <0.05)。治疗前后两组感觉运动节律(SMR)波、β波、θ波均无显著差异(p >0.05)。结论:调泻益智方加托莫西汀加生物反馈治疗对adhd症状的改善作用优于生物反馈治疗和托莫西汀联合治疗,表现为中医评分、SNAP-IV评分和CGI评分的降低。然而,为了验证这些发现,调查将需要使用更大的样本量进行。
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来源期刊
CiteScore
1.00
自引率
33.30%
发文量
490
审稿时长
4-8 weeks
期刊介绍: We seek to encourage pharmaceutical and allied research of tropical and international relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and the healthcare professionals. We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). Although primarily devoted to original research papers, we welcome reviews on current topics of special interest and relevance.
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