Igor Barbosa Lima, Betania Mara Alvarenga, Priscila Izabel Santos de Tótaro, Fernanda Boratto, Elaine Amaral Leite, Pedro Pires Goulart Guimaraes
{"title":"Improved Antiproliferative Activity of Doxorubicin-Loaded Calcium Phosphate Nanoparticles Against Melanoma Cells","authors":"Igor Barbosa Lima, Betania Mara Alvarenga, Priscila Izabel Santos de Tótaro, Fernanda Boratto, Elaine Amaral Leite, Pedro Pires Goulart Guimaraes","doi":"10.1590/1678-4324-2023220572","DOIUrl":null,"url":null,"abstract":"HIGHLIGHTS N-Dox has higher activity against A-375 cells than free doxorubicin. The formulation has higher selectivity indices than free doxorubicin. Treatment induced senescence and no colonies recovered after short-term exposure.","PeriodicalId":9169,"journal":{"name":"Brazilian Archives of Biology and Technology","volume":"158 1","pages":"0"},"PeriodicalIF":1.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Archives of Biology and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1678-4324-2023220572","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
HIGHLIGHTS N-Dox has higher activity against A-375 cells than free doxorubicin. The formulation has higher selectivity indices than free doxorubicin. Treatment induced senescence and no colonies recovered after short-term exposure.