Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

IF 3.4 Q2 CHEMISTRY, MEDICINAL ADMET and DMPK Pub Date : 2023-10-24 DOI:10.5599/admet.2088
Rabinarayan Parhi, Partha Pratim Kaishap, Goutam Kumar Jena
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Abstract

Background and Purpose: Safe and effective drug delivery is crucial for the treatment of cancer, which is quite impossible to achieve through traditional methods. Among all types of cancer, skin melanoma is known for its aggressive metastasizing ability and an unprecedented higher degree of lethalness, limiting the overall therapeutic efficacy. Here, we focus on the different types of nanomaterials (NMs) and their drug delivery applications against melanoma. Experimental Approach: All relevant publications, including research papers, reviews, chapters and patents, were assessed using search engines such as Scopus and PubMed, up to the end of August of 2023. The keywords used in the search were: nanomaterials, melanoma, drug delivery routes for melanoma, and nanomaterial-based drug delivery systems (DDS). Most of the publications out of 234 cited in this review are from the last five years. Key Results: The recent advancement and mechanism of action of various NMs against melanoma, including inorganic metallic and carbon-based NMs, organic polymeric and lipid-based NMs, and cell-derived vesicles are discussed. We also focus on the application of different NMs in the delivery of therapeutic agents for melanoma therapy. In addition, the skin and melanoma, genetic mutation and pathways for melanoma, conventional treatment options, and delivery routes for therapeutic agents are also discussed briefly. Conclusion: There are few NM-based DDS developed in the lab set up recently. The findings of this review will pave the path for the development of NM-based DDS on an industrial scale and help in the better management of skin melanoma.
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基于纳米材料的黑色素瘤药物递送系统的最新进展
背景与目的:安全有效的给药对于癌症的治疗至关重要,这是传统方法无法实现的。在所有类型的癌症中,皮肤黑色素瘤以其侵袭性转移能力和前所未有的高致死率而闻名,限制了整体治疗效果。在这里,我们专注于不同类型的纳米材料(NMs)及其对黑色素瘤的药物递送应用。实验方法:截至2023年8月底,使用Scopus和PubMed等搜索引擎对所有相关出版物(包括研究论文、综述、章节和专利)进行评估。搜索中使用的关键词是:纳米材料、黑色素瘤、黑色素瘤的药物传递途径和基于纳米材料的药物传递系统(DDS)。在这篇综述中引用的234篇论文中,大多数都是最近5年发表的。综述了无机金属基、碳基NMs、有机聚合物基、脂质NMs、细胞源性囊泡等多种NMs抗黑色素瘤的最新进展及其作用机制。我们还关注不同NMs在黑色素瘤治疗药物输送中的应用。此外,皮肤和黑色素瘤,基因突变和黑色素瘤的途径,传统的治疗方案,以及药物的递送途径也进行了简要的讨论。结论:近年来建立的实验室研制的纳米基DDS较少。本综述的研究结果将为基于纳米颗粒的DDS的工业化发展铺平道路,并有助于更好地治疗皮肤黑色素瘤。
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来源期刊
ADMET and DMPK
ADMET and DMPK Multiple-
CiteScore
4.40
自引率
0.00%
发文量
22
审稿时长
4 weeks
期刊介绍: ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
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