The Effect of the Hierarchical Chain Nursing Model Combined with Feilike Mixture Treatment on the Disappearance of Fever and Cough in Pediatric Pneumonia

Abstract

In this study, we examined the effect of the hierarchical chain nursing model combined with Feilike mixture treatment on the disappearance of fever and cough in children with pneumonia. Eighty children with pneumonia who were admitted to our hospital from March 2021 to July 2022 were selected as the study subjects. The children were divided into the observation group ( n = 40) and the experimental group ( n = 40) based on the treatment interventions that they received. The observation group underwent routine treatment plus hierarchical chain nursing intervention, while the experimental group were treated with the Feilike mixture in addition to the interventions provided to the observation group. The clinical efficacy and symptom disappearance time were compared between the two groups. Subsequently, an in vitro cell experiment was conducted using lipopolysaccharide-induced RAW 264.7 inflammatory cells to evaluate the anti-inflammatory effects of the Feilike mixture. Immunoblotting was performed to measure tumor necrosis factor- α , interleukin (IL)-6, and IL-1 β expression, further validating the mechanism of action of the Feilike mixture in treating children with pneumonia. The total effective rate in the observation group was 77.5% compared with 97.5% in the experimental group ( P <0.05). The disappearance time of fever, cough, and pulmonary rales in the experimental group was significantly shorter than in the observation group ( P <0.05). In the in vitro experiment, compared with the control group, the inflammatory factor concentrations in the model group were significantly increased ( P <0.05). The Feilike mixture at various doses exhibited significant inhibitory effects on inflammatory factor expression. Western blot analysis revealed that the expression of relevant proteins was elevated in the model group compared with the control group ( P <0.05). After treatment with the Feilike mixture, protein expression was significantly reduced compared with the model group ( P <0.05). The application of the hierarchical chain nursing model combined with the Feilike mixture in children with pneumonia showed promising results. This combined intervention effectively improved the therapeutic efficacy and promoted the rapid disappearance of symptoms, such as fever, cough, and pulmonary rales. Furthermore, the in vitro results demonstrated that the Feilike mixture significantly reduced inflammatory factor concentrations, while inhibiting the expression of related proteins.