Marc Wiartalla, Frederik Berg, Jahn Kühn, Mateusz Buglowski, Stefan Kowalewski, André Stollenwerk, Christian Bleilevens
{"title":"A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles","authors":"Marc Wiartalla, Frederik Berg, Jahn Kühn, Mateusz Buglowski, Stefan Kowalewski, André Stollenwerk, Christian Bleilevens","doi":"10.1515/cdbme-2023-1081","DOIUrl":null,"url":null,"abstract":"Abstract Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup. In this work, we present a fully automated normothermic machine perfusion (NMP) system as an experimental research platform. The perfusion system is intended as a tool for researching the effects of different perfusion strategies on the kidney. To enable the automation, the NMP system consists of a blood pressure control, a circulation volume level control and a pH-regulation component. The setup is realized as a medical cyber-physical system consisting of networked embedded microcontroller nodes.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"35 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Directions in Biomedical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/cdbme-2023-1081","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup. In this work, we present a fully automated normothermic machine perfusion (NMP) system as an experimental research platform. The perfusion system is intended as a tool for researching the effects of different perfusion strategies on the kidney. To enable the automation, the NMP system consists of a blood pressure control, a circulation volume level control and a pH-regulation component. The setup is realized as a medical cyber-physical system consisting of networked embedded microcontroller nodes.
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