{"title":"Mathematical modeling and optimal control of a deterministic SHATR model of HIV/AIDS with possibility of rehabilitation: a dynamic analysis","authors":"Pankaj Singh Rana, Nitin Sharma, Anupam Priyadarshi","doi":"10.5556/j.tkjm.55.2024.5109","DOIUrl":null,"url":null,"abstract":"In the present work, we developed a deterministic SHATR (Susceptible - HIV infected -AIDS infected - Antiretroviral Treatment - Recovered) compartment model for HIV/AIDS. This model considers the disease outbreak due to a lack of awareness and treatment. The steady states of the proposed model system are obtained and analyzed by using the nonlinear stability theory of differential equations. The basic reproduction number is derived and explored to determine the stability and sensitivity index of some important relative parameters. Further, to know the global behavior of the model one parameter bifurcation study is discussed. Moreover, the optimal control theory has been applied to identify the optimal strategy by taking treatment and awareness for safe intercourse as control parameters. The control problem is solved analytically by using Pontryagin’s maximum principle. Finally, the model is simulated to describe the optimality under various assumptions and the stability of equilibrium points.","PeriodicalId":45776,"journal":{"name":"Tamkang Journal of Mathematics","volume":"74 1","pages":"0"},"PeriodicalIF":0.7000,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tamkang Journal of Mathematics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5556/j.tkjm.55.2024.5109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATHEMATICS","Score":null,"Total":0}
引用次数: 0
Abstract
In the present work, we developed a deterministic SHATR (Susceptible - HIV infected -AIDS infected - Antiretroviral Treatment - Recovered) compartment model for HIV/AIDS. This model considers the disease outbreak due to a lack of awareness and treatment. The steady states of the proposed model system are obtained and analyzed by using the nonlinear stability theory of differential equations. The basic reproduction number is derived and explored to determine the stability and sensitivity index of some important relative parameters. Further, to know the global behavior of the model one parameter bifurcation study is discussed. Moreover, the optimal control theory has been applied to identify the optimal strategy by taking treatment and awareness for safe intercourse as control parameters. The control problem is solved analytically by using Pontryagin’s maximum principle. Finally, the model is simulated to describe the optimality under various assumptions and the stability of equilibrium points.
期刊介绍：
To promote research interactions between local and overseas researchers, the Department has been publishing an international mathematics journal, the Tamkang Journal of Mathematics. The journal started as a biannual journal in 1970 and is devoted to high-quality original research papers in pure and applied mathematics. In 1985 it has become a quarterly journal. The four issues are out for distribution at the end of March, June, September and December. The articles published in Tamkang Journal of Mathematics cover diverse mathematical disciplines. Submission of papers comes from all over the world. All articles are subjected to peer review from an international pool of referees.
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