{"title":"Neuromuscular Joint Function Impairment in Leptin-Resistant Mice","authors":"V. A. Prikhodko, T. M. Matuzok, S. V. Okovityi","doi":"10.33647/2074-5982-19-3-77-81","DOIUrl":null,"url":null,"abstract":"The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db + / + m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii . We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.","PeriodicalId":40514,"journal":{"name":"Avances en Biomedicina","volume":"2012 1","pages":"0"},"PeriodicalIF":0.1000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avances en Biomedicina","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33647/2074-5982-19-3-77-81","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db + / + m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii . We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.
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