JUVENILE GRANULOSA CELL TUMOR OF THE OVARY IN A CHILD: CLINICAL CASE AND BIBLIOGRAPHICAL REVIEW

Q4 Medicine Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-06-01 DOI:10.24110/0031-403x-2023-102-3-183-188

E.O. Bezdolnova, M.S. Kubirov, A.A. Kirillov, V.V. Gorev, E.V. Kumirova

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Abstract

Juvenile granulosa cell tumor of the ovaries is a rare disease in pediatric oncology. Mostly seen in girls and young women in premenarchal age (median age 10 y/o) and is more aggressive than the adult type, but has a favorable prognosis, especially in its early stages. Large reviews and studies include patients with bot adult and juvenile types granulosa cell tumor. Due to the limited cohort of pediatric patients, there are no standards for the treatment of juvenile granulosa cell tumor in pediatric practice. Therefore, diagnosis, treatment, and long-term follow-up for this disease are based on recommendations for an adult cohort. Adjuvant chemotherapy as a curative option is used in advanced stages above the FIGO IC. For the IC stage, the issue of prescribing adjuvant chemotherapy remains debatable. Article represents analysis of the bibliographical data of the largest studies on the treatment of this disease as well as clinical case of a 15 y/o patient with juvenile granulosa cell tumor of the right ovary who had received complex treatment in the Oncological Department of the Morozov Children’s City Clinical Hospital (Moscow, Russia).

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1例儿童卵巢幼年性颗粒细胞瘤:临床病例及文献复习

小儿卵巢颗粒细胞瘤是小儿肿瘤中一种罕见的疾病。多见于青春期前(中位年龄10岁)的女孩和年轻女性，比成人型更具侵袭性，但预后良好，特别是在早期阶段。大量的综述和研究包括成人和青少年型颗粒细胞肿瘤患者。由于儿童患者队列有限，儿科实践中对幼年颗粒细胞瘤的治疗尚无标准。因此，对这种疾病的诊断、治疗和长期随访是基于对成人队列的建议。辅助化疗作为一种治疗选择用于FIGO IC以上的晚期。对于IC期，处方辅助化疗的问题仍有争议。本文分析了有关该病治疗的最大规模研究的文献资料，以及在莫罗佐夫儿童城市临床医院(莫斯科，俄罗斯)肿瘤科接受综合治疗的15岁儿童右卵巢颗粒细胞瘤患者的临床病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.