#35904 Mitochondrial dysfunction as triggering in complex regional pain syndrome

Paola María Robert Vélez, Lucia Elizabeth Alvarez Palazuelos, Andrea Virginia Ruiz-Ramírez, Carlos Francisco Rivera Quiles, Miguel Alejandro Dávalos Benítez, Moctezuma Ilhuicamina Cabrera Salaiza
{"title":"#35904 Mitochondrial dysfunction as triggering in complex regional pain syndrome","authors":"Paola María Robert Vélez, Lucia Elizabeth Alvarez Palazuelos, Andrea Virginia Ruiz-Ramírez, Carlos Francisco Rivera Quiles, Miguel Alejandro Dávalos Benítez, Moctezuma Ilhuicamina Cabrera Salaiza","doi":"10.1136/rapm-2023-esra.415","DOIUrl":null,"url":null,"abstract":"<h3></h3> <b>Please confirm that an ethics committee approval has been applied for or granted:</b> Not relevant (see information at the bottom of this page) <h3>Background and Aims</h3> Complex regional pain syndrome (CRPS) is characterized by being disproportionate to the triggering event; the associated characteristics are autonomic dysfunction, swelling of the zone of affection, and even changes in the skin, such as dystrophy and rigidity. The pathophysiology is still unknown; it has been mentioned as a multifactorial disorder, with an exaggerated immune response to the triggering event, abnormal vasomotor function, and even maladaptive neuroplasticity. This study aimed to evaluate the differently expressed genes (DEG) between 4 patients with complex regional pain syndrome vs. healthy controls and analyze the pathways intervening. <h3>Methods</h3> Material/Methods: The gene expression dataset GSE47603 was downloaded from the GEO database, and DEG obtained. The highest up-regulated genes were examined in the String platform for the protein-protein interaction (PPI) network. <h3>Results</h3> Results: 60 primary genes up-regulated were identified according to the Log2-fold change statistics. The network for the 60 genes was sub-selected in clusters in STRING, obtaining a network of 20 nodes, 24 edges, and a PPI enrichment p-value of 3.73e-11. The principal intervening pathways were mitochondrial ATP synthesis, the electron transport chain, and lysosome vesicle biogenesis. <h3>Conclusions</h3> We found a relevant participation of mitochondrial metabolism in the PPI network that has not been mentioned before as a pain onset in CRPS, but at the same time presence of pain has been reported in patients with mitochondrial disease, the essential role that it could play in the sudden development of pain in CRPS needs to be further analyzed.","PeriodicalId":80519,"journal":{"name":"Archaeologia aeliana, or, Miscellaneous tracts relating to antiquity","volume":"49 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archaeologia aeliana, or, Miscellaneous tracts relating to antiquity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/rapm-2023-esra.415","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Please confirm that an ethics committee approval has been applied for or granted: Not relevant (see information at the bottom of this page)

Background and Aims

Complex regional pain syndrome (CRPS) is characterized by being disproportionate to the triggering event; the associated characteristics are autonomic dysfunction, swelling of the zone of affection, and even changes in the skin, such as dystrophy and rigidity. The pathophysiology is still unknown; it has been mentioned as a multifactorial disorder, with an exaggerated immune response to the triggering event, abnormal vasomotor function, and even maladaptive neuroplasticity. This study aimed to evaluate the differently expressed genes (DEG) between 4 patients with complex regional pain syndrome vs. healthy controls and analyze the pathways intervening.

Methods

Material/Methods: The gene expression dataset GSE47603 was downloaded from the GEO database, and DEG obtained. The highest up-regulated genes were examined in the String platform for the protein-protein interaction (PPI) network.

Results

Results: 60 primary genes up-regulated were identified according to the Log2-fold change statistics. The network for the 60 genes was sub-selected in clusters in STRING, obtaining a network of 20 nodes, 24 edges, and a PPI enrichment p-value of 3.73e-11. The principal intervening pathways were mitochondrial ATP synthesis, the electron transport chain, and lysosome vesicle biogenesis.

Conclusions

We found a relevant participation of mitochondrial metabolism in the PPI network that has not been mentioned before as a pain onset in CRPS, but at the same time presence of pain has been reported in patients with mitochondrial disease, the essential role that it could play in the sudden development of pain in CRPS needs to be further analyzed.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
线粒体功能障碍是复杂局部疼痛综合征的触发因素
背景和目的:复杂区域性疼痛综合征(CRPS)的特点是与触发事件不成比例;相关特征是自主神经功能障碍,情感区肿胀,甚至皮肤变化,如营养不良和僵硬。病理生理机制尚不清楚;它被认为是一种多因素疾病,对触发事件的免疫反应过度,血管舒缩功能异常,甚至神经可塑性不良。本研究旨在评估4例复杂局部疼痛综合征患者与健康对照者的差异表达基因(DEG),并分析其干预途径。方法材料/方法:从GEO数据库下载基因表达数据集GSE47603,获取DEG。在蛋白-蛋白相互作用(PPI)网络的String平台上检测了上调最高的基因。结果:经log2倍变化统计,共鉴定出60个上调的原代基因。在STRING中对60个基因的网络进行分组选择,得到一个20节点、24边的网络,PPI富集p值为3.73e-11。主要的干预途径是线粒体ATP合成、电子传递链和溶酶体囊泡的生物发生。结论我们发现线粒体代谢相关参与PPI网络,与CRPS疼痛发病相关,但在线粒体疾病患者中存在疼痛的同时,其在CRPS疼痛突然发生中可能发挥的重要作用有待进一步分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
#35807 Erector spinae block for percutaneous kyphoplasty anesthetic management in high-risk patients: a case report #35918 A randomized control trial to evaluate the effects of Ketofol versus propofol on cerebral oxygenation in patients undergoing Trans-sphenoidal pituitary surgery under total intravenous anesthesia #35931 Regional anaesthesia for intubation and maintenance in myasthenia gravis patient with bilateral renal calculi #34666 Case report: Ablation of renal tumour in high bmi patient under single shot paravertebral and remifentanil #35938 Venovenous ECMO in near fatal ashtma: case report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1