{"title":"Fatal podophyllin poisoning with multi-organ toxicity: A case report","authors":"BhaktiU Sarangi, Shridhar Jadhav, Ajay Walimbe, Manikiran Reddy, Siddhi Gawhale, RHema Priya","doi":"10.4103/jpcc.jpcc_47_23","DOIUrl":null,"url":null,"abstract":"Accidental poisoning with household products is one of the leading causes of involuntary injuries among children in low- and middle-income countries. Podophyllin poisoning is a rare and potentially fatal occurrence. The podophyllotoxin is a lipid-soluble cytotoxic compound with no antidote and its toxicity includes life-threatening neurological and multisystem complications. We report a case of a 2-year-old girl with accidental podophyllin poisoning causing multi-organ dysfunction who did not survive despite timely aggressive support and explore the possibility of early use of activated charcoal and role of extra-corporeal therapies such as hemoperfusion as a life-saving measure in such situations.","PeriodicalId":34184,"journal":{"name":"Journal of Pediatric Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Critical Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jpcc.jpcc_47_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Accidental poisoning with household products is one of the leading causes of involuntary injuries among children in low- and middle-income countries. Podophyllin poisoning is a rare and potentially fatal occurrence. The podophyllotoxin is a lipid-soluble cytotoxic compound with no antidote and its toxicity includes life-threatening neurological and multisystem complications. We report a case of a 2-year-old girl with accidental podophyllin poisoning causing multi-organ dysfunction who did not survive despite timely aggressive support and explore the possibility of early use of activated charcoal and role of extra-corporeal therapies such as hemoperfusion as a life-saving measure in such situations.
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