tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2023-09-13 DOI:10.1159/000533811

Dan Li, Xian Xie, Ni Yin, Xueqin Wu, Bin Yi, Hao Zhang, Wei Zhang

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Abstract

Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including regulation of mRNA stability, transcription, translation, direct interaction with proteins and as epigenetic factors, etc. Recent studies have shown that tsRNAs are also closely related to renal disease. In clinical acute kidney injury (AKI) patients and preclinical AKI models, the production and differential expression of tsRNAs in renal tissue and plasma were observed. Decreased expression of tsRNAs was also found in urine exosomes from chronic kidney disease patients. Dysregulation of tsRNAs also appears in models of nephrotic syndrome and patients with lupus nephritis. And specific tsRNAs were found in high glucose model in vitro and in serum of diabetic nephropathy patients. In addition, tsRNAs were also differentially expressed in patients with kidney cancer and transplantation. Key Messages: In the present review, we have summarized up-to-date works and reviewed the relationship and possible mechanisms between tsRNAs and kidney diseases.

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trna衍生的小RNA:肾脏疾病中一种新的调节小非编码RNA

& lt; b> & lt; i>背景:& lt; / i> & lt; / b>tRNA衍生的小rna (tsRNAs)是一类新兴的非编码小rna，由tRNA裂解产生。& lt; b> & lt; i>简介:& lt; / i> & lt; / b>随着高通量测序技术的发展，tsRNAs的多种生物学作用逐渐被揭示，包括调控mRNA的稳定性、转录、翻译、与蛋白质的直接相互作用以及作为表观遗传因子等。最近的研究表明，tsRNAs也与肾脏疾病密切相关。在临床急性肾损伤(AKI)患者和临床前AKI模型中，观察肾组织和血浆中tsRNAs的产生和差异表达。在慢性肾病患者的尿外泌体中也发现tsRNAs表达降低。tsRNAs的失调也出现在肾病综合征模型和狼疮肾炎患者中。并在体外高糖模型和糖尿病肾病患者血清中发现特异性tsRNAs。此外，tsRNAs在肾癌和移植患者中也存在差异表达。& lt; b> & lt; i>关键信息:& lt; / i> & lt; / b>本文就tsRNAs与肾脏疾病的关系及其可能的机制进行综述。

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