{"title":"Multipotent Stromal Stem Cell Approach in Alleviating Autophagy Beclin-1/XBP-1/STAT5A/PTEN Signaling Pathways in Novodrin-induced Liver Dysfunction","authors":"Mai O. Kadry, Rehab M. Abdel-Megeed","doi":"10.14218/ge.2023.00052","DOIUrl":null,"url":null,"abstract":"Background and objectiveAutophagy is the fundamental cell survival machinery that enables cells to respond to metabolic stress by recycling and degrading intracellular components to generate energy and macromolecular precursors. Bone marrow-derived mesenchymal stem cells (MSCs), possess the unique ability of self-renewal and development into specialized cells, and long-lived cells with specific metabolic needs. It has been demonstrated that autophagy is essential for MSC differentiation, quiescence, activation, and self-renewal. Thus, the hypothesis that autophagy influences bone marrow-derived MSC post-novodrin-prompted liver dysfunction was investigated in the present study.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"76 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene expression","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14218/ge.2023.00052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objectiveAutophagy is the fundamental cell survival machinery that enables cells to respond to metabolic stress by recycling and degrading intracellular components to generate energy and macromolecular precursors. Bone marrow-derived mesenchymal stem cells (MSCs), possess the unique ability of self-renewal and development into specialized cells, and long-lived cells with specific metabolic needs. It has been demonstrated that autophagy is essential for MSC differentiation, quiescence, activation, and self-renewal. Thus, the hypothesis that autophagy influences bone marrow-derived MSC post-novodrin-prompted liver dysfunction was investigated in the present study.
期刊介绍：
Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.
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