{"title":"Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis","authors":"Nicholas A. Isley, Fabrice Gallou","doi":"10.1002/hlca.202300143","DOIUrl":null,"url":null,"abstract":"<p>A scalable and environmentally benign protocol for a Suzuki–Miyaura cross-coupling in water using vitamin E derived surfactant TPGS-750-M is reported. The protocol is the most simple and standard for such transformations under micellar catalysis that has been amply utilized within our own research and development portfolio over the last decade. The impact of the synthetic procedure is reenforced by green Process Mass Intensity and Total Carbon Release metrics.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202300143","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hlca.202300143","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A scalable and environmentally benign protocol for a Suzuki–Miyaura cross-coupling in water using vitamin E derived surfactant TPGS-750-M is reported. The protocol is the most simple and standard for such transformations under micellar catalysis that has been amply utilized within our own research and development portfolio over the last decade. The impact of the synthetic procedure is reenforced by green Process Mass Intensity and Total Carbon Release metrics.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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