SARS-CoV-2 post-vaccination adverse reports: A review

IF 0.1 0 HUMANITIES, MULTIDISCIPLINARY Vestnik Sankt-Peterburgskogo Universiteta-Iskusstvovedenie Pub Date : 2023-01-01 DOI:10.21638/spbu11.2023.202
Elena Proskurnina, Denis Ivanov, Alexander Redko
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Abstract

Acute respiratory infection caused by the SARS-CoV-2 coronavirus was the cause of the pandemic announced in March 2020. To prevent this disease, various vaccines have been developed and introduced into mass use, including on an innovative gene platform. The aim of the review is to analyze foreign literature on post-vaccination complications with the use of foreign vaccines, as well as whole-virion vaccines for the period 2021 — January 2023. The sources used in the publication were obtained from the Medline database, as well as articles in peer-reviewed journals and official reports. Post-vaccination complications are associated with specific damage to organs or systems either directly by the vaccine itself or indirectly as a result of exacerbation of the chronic process. The pathogenesis of post-vaccination complications depends on the composition of the vaccine. All complications were grouped by organs and systems. Vaccines containing SARS-CoV-2 antigens can activate autoimmune reactions due to homology, as well as activation of existing reactions in predisposed patients, which is confirmed by the effectiveness of immunosuppressive therapy. Innovative platforms using gene technologies are so complex and profoundly active that they can be introduced into broad medical practice only after a thorough and comprehensive study of the effects and mechanisms. Scientific achievements should follow the ethical principles of healing, and above all primum non nocere. Experts around the world emphasize the need for continued monitoring of people’s condition in order to protect their health and assess the long-term safety of drugs.
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SARS-CoV-2疫苗接种后不良报告综述
由SARS-CoV-2冠状病毒引起的急性呼吸道感染是2020年3月宣布的大流行的原因。为了预防这种疾病,已经开发了各种疫苗并投入大规模使用,包括在一个创新的基因平台上。本综述的目的是分析2021年至2023年1月期间使用外国疫苗和全病毒粒子疫苗接种后并发症的国外文献。该出版物中使用的来源来自Medline数据库,以及同行评议期刊和官方报告中的文章。疫苗接种后并发症与器官或系统的特异性损伤有关,或直接由疫苗本身引起,或间接由于慢性过程的恶化而引起。疫苗接种后并发症的发病机制取决于疫苗的成分。所有并发症按器官和系统分类。含有SARS-CoV-2抗原的疫苗由于同源性可以激活自身免疫反应,也可以激活易感患者的现有反应,免疫抑制治疗的有效性证实了这一点。利用基因技术的创新平台是如此复杂和深刻的活跃,只有在对其作用和机制进行深入和全面的研究之后,才能将其引入广泛的医疗实践。科学成就应该遵循治疗的伦理原则,最重要的是不伤害他人。世界各地的专家强调有必要继续监测人们的状况,以保护他们的健康并评估药物的长期安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.20
自引率
50.00%
发文量
9
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