An electrochemical immunosensor based on a graphene/multi-wall carbon nanotube composite platform for the detection of cardiovascular marker C-reactive protein

IF 5.5 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Carbon Letters Pub Date : 2023-11-02 DOI:10.1007/s42823-023-00629-6

Jingjing Du, Yuedong Ma, Yanyun Wang

{"title":"An electrochemical immunosensor based on a graphene/multi-wall carbon nanotube composite platform for the detection of cardiovascular marker C-reactive protein","authors":"Jingjing Du, Yuedong Ma, Yanyun Wang","doi":"10.1007/s42823-023-00629-6","DOIUrl":null,"url":null,"abstract":"<div><p>This paper presents an electrochemical immunosensor using a graphene/multi-walled carbon nanotube (MWCNT) composite platform for detecting the cardiovascular marker C-reactive protein (CRP). The immunosensor exhibited a linear detection range of 0.20–100 ng/mL CRP with a low limit of detection reaching 0.081 ng/mL. The composite material provided a 3D porous structure that allowed efficient antibody immobilization and minimized steric hindrance. The sensor showed high specificity, with minimal response to interfering substances. Using differential pulse voltammetry, the immunosensor demonstrated exceptional precision, rapid detection, and a direct correlation between CRP concentration and sensor response current. Overall, this work highlights the potential of the graphene/MWCNT composite platform as a robust tool for early CRP detection and cardiovascular disease risk assessment. The immunosensor provides sensitive and selective CRP quantification that could enable timely clinical intervention for at-risk individuals.</p></div>","PeriodicalId":506,"journal":{"name":"Carbon Letters","volume":"34 1","pages":"519 - 528"},"PeriodicalIF":5.5000,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbon Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42823-023-00629-6","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

This paper presents an electrochemical immunosensor using a graphene/multi-walled carbon nanotube (MWCNT) composite platform for detecting the cardiovascular marker C-reactive protein (CRP). The immunosensor exhibited a linear detection range of 0.20–100 ng/mL CRP with a low limit of detection reaching 0.081 ng/mL. The composite material provided a 3D porous structure that allowed efficient antibody immobilization and minimized steric hindrance. The sensor showed high specificity, with minimal response to interfering substances. Using differential pulse voltammetry, the immunosensor demonstrated exceptional precision, rapid detection, and a direct correlation between CRP concentration and sensor response current. Overall, this work highlights the potential of the graphene/MWCNT composite platform as a robust tool for early CRP detection and cardiovascular disease risk assessment. The immunosensor provides sensitive and selective CRP quantification that could enable timely clinical intervention for at-risk individuals.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基于石墨烯/多壁碳纳米管复合平台的电化学免疫传感器，用于检测心血管标志物 C 反应蛋白

本文介绍了一种利用石墨烯/多壁碳纳米管（MWCNT）复合平台检测心血管标志物 C 反应蛋白（CRP）的电化学免疫传感器。该免疫传感器的线性检测范围为 0.20-100 纳克/毫升 CRP，检测低限为 0.081 纳克/毫升。复合材料具有三维多孔结构，可有效固定抗体，并将立体阻碍降至最低。该传感器具有高度特异性，对干扰物质的反应极小。利用差分脉冲伏安法，该免疫传感器表现出了极高的精度、快速检测能力以及 CRP 浓度与传感器响应电流之间的直接相关性。总之，这项工作凸显了石墨烯/MWCNT 复合平台作为早期 CRP 检测和心血管疾病风险评估的强大工具的潜力。该免疫传感器可提供灵敏且有选择性的 CRP 定量，从而对高危人群进行及时的临床干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Carbon Letters CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

7.30

自引率

20.00%

发文量

118

期刊介绍： Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.