PROSPECTS FOR THE USE OF UMBILICAL CORD BLOOD IN THE TREATMENT OF DISEASES OF THE CARDIOVASCULAR SYSTEM

Biotechnologia Acta Pub Date : 2023-08-31 DOI:10.15407/biotech16.04.031

I.Y. Shchenyavskyi

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Abstract

Cardiovascular diseases are currently the most common cause of death worldwide. In this regard, experimental and clinical studies of the effectiveness of therapy of ischemic and non-ischemic heart diseases using stem cells are relevant. The purpose of this review was to evaluate the prospects of using cord blood stem cells in the treatment of cardiovascular diseases. Methods. The following databases were searched: «BIGG International database of GRADE guidelines», “Database of GRADE EtD's and Guidelines”, “Dynamed”, “ebmafrica.net”, “ECRI”, “MAGIC authoring and publication platform (MAGICapp)”, “National Health and Medical Research Council (NHMRC) portal”, “NICE Evidence”, “Pubmed”, “TRIP database”, “U.S. Preventive Services Task Force”. Results. An analysis of research related to this problem, which was conducted in recent years, was made, and considerations regarding the prospects of using umbilical cord blood in the treatment of diseases of the cardiovascular system were outlined. Conclusions. Despite some successes, realizing the full potential of cord blood stem cells in the treatment of cardiovascular diseases still requires further serious, targeted and well-funded research and expanded clinical trials.

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脐带血在心血管疾病治疗中的应用前景

心血管疾病目前是全世界最常见的死亡原因。在这方面，利用干细胞治疗缺血性和非缺血性心脏病的有效性的实验和临床研究是相关的。本综述的目的是评价脐带血干细胞在心血管疾病治疗中的应用前景。方法。检索的数据库如下:«BIGG国际GRADE指南数据库»，“GRADE EtD和指南数据库”，“Dynamed”，“ebmafrica.net”，“ECRI”，“MAGIC创作和出版平台(MAGICapp)”，“国家卫生和医学研究委员会(NHMRC)门户网站”，“NICE Evidence”，“Pubmed”，“TRIP数据库”，“U.S. . gov . gov”预防服务工作队”。结果。本文对近年来的相关研究进行了分析，并对脐带血在心血管系统疾病治疗中的应用前景进行了展望。结论。尽管取得了一些成功，但要充分发挥脐带血干细胞治疗心血管疾病的潜力，仍需要进一步认真、有针对性和资金充足的研究和扩大临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biotechnologia Acta

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20 weeks