Dietary fat, telomere length and cognitive function: unravelling the complex relations.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current opinion in lipidology Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI:10.1097/MOL.0000000000000900

Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló

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Abstract

Purpose of review: The review aims to explore the recent evidence on the associations between different dietary fat intake and cognitive function, and to understand the role of telomere length in this relationship.

Recent findings: Clinical and preclinical studies included in this review suggest that dietary fat intake is associated with cognitive function and telomere length. High intake of saturated fats and trans fats, commonly found in ultra-processed foods, appears to have negative effects on cognitive function and telomere length, while other dietary fats, such as omega-3 polyunsaturated fatty acids and monounsaturated fatty acids are associated with improved cognitive performance and reduced telomere attrition. Controversial results related to omega-6 polyunsaturated fatty acids intake and its impact on cognitive function were found. Dietary fats may affect telomere length and cognition through oxidative stress, inflammation, and insulin resistance.

Summary: The current review illustrated the relationship between dietary fat and cognitive function by focusing on the role of telomere length as a potential intermediator. More future studies are required, however, in order to develop targeted interventions aimed at preserving cognitive well-being throughout life.

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膳食脂肪、端粒长度与认知功能:揭开复杂关系。

综述目的:本综述旨在探讨不同膳食脂肪摄入量与认知功能之间关系的最新证据，并了解端粒长度在这一关系中的作用。最新发现:本综述中包括的临床和临床前研究表明，膳食脂肪摄入量与认知功能和端粒长度有关。过量摄入超加工食品中常见的饱和脂肪和反式脂肪，似乎对认知功能和端粒长度有负面影响，而其他膳食脂肪，如omega-3多不饱和脂肪酸和单不饱和脂肪酸，则与提高认知能力和减少端粒损耗有关。发现了有关摄入omega-6多不饱和脂肪酸及其对认知功能影响的有争议的结果。膳食脂肪可能通过氧化应激、炎症和胰岛素抵抗影响端粒长度和认知。摘要:目前的综述通过关注端粒长度作为潜在中介的作用来说明膳食脂肪与认知功能之间的关系。然而，为了开发有针对性的干预措施，以保持一生的认知健康，还需要更多的未来研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.