Chemical profile and in vivo anti-hyperlipidaemic activity of chloroform fraction of Zygophyllum indicum in Triton X-100 induced hyperlipidaemic rats

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-16 DOI:10.1080/14786419.2023.2286612

Atiq-ur- Rehman

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Abstract

Anti-hyperlipidaemic effect of chloroform fraction of aerial parts of Zygophyllum indicum (Fagonia indica Burm.f.) was studied in rats. Adult Wistar albino rats were distributed into five groups. Rats of all groups except group I were given an intraperitoneal injection (Triton X-100) to induce hyperlipidaemia. Groups (I and II) served as normal and hyperlipidaemic control groups respectively. Group III and group IV were administered with 250 and 500 mg/kg chloroform fraction of the plant respectively after 18 h of inducing hyperlipidaemia. Group V was given 10 mg/kg of the standard atorvastatin. Chloroform fraction had significant (p < 0.05) hypolipidaemic effects on lipid profile and biochemical parameters with a protective effect on the liver in comparison to group II. F. indica with hypolipidaemic effect is useful in the management of hyperlipidaemia. Chloroform fraction with its constituents can be used as an antihyperlipidaemic supplement in developing countries for the development of novel therapeutic agents.

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枸杞子氯仿部位对Triton X-100诱导的高脂血症大鼠的化学性质及体内抗高脂血症活性。

以大鼠为实验对象，研究了梧桐(Fagonia indica Burm.f.)地上部分氯仿部位的降血脂作用。将成年Wistar白化大鼠分为5组。除1组外，其余各组大鼠均腹腔注射Triton X-100诱导高脂血症。ⅰ组为正常对照组，ⅱ组为高脂血症对照组。III组和IV组在诱导高脂血症18 h后，分别给予250和500 mg/kg的植物氯仿部位。V组给予标准阿托伐他汀10 mg/kg。氯仿馏分有显著差异(p < 0.05)。具有降血脂作用的籼稻在高脂血症的治疗中是有用的。在发展中国家，氯仿及其成分可作为抗高脂血症的补充剂，用于开发新型治疗剂。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.