Clinical efficacy and safety of endovascular treatment for patients with wake-up stroke with large vessel occlusion guided by NCCT-ASPECTS.

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY Interventional Neuroradiology Pub Date : 2023-12-06 DOI:10.1177/15910199231217145

Qinglin Xu, Yigang Chen, Xu Zheng, Yun Jiang, Chuan Xu, Qingqing Gao, Feina Shi, Jinhua Zhang

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Abstract

Objective: To evaluate the clinical efficacy and safety of 6 to 24 h endovascular therapy (EVT) in patients with wake-up stroke (WUS) with acute large vessel occlusion (LVO) of the anterior circulation guided by noncontrast computed tomography-Alberta stroke program early CT score (NCCT-ASPECTS).

Methods: Fifty-three patients with WUS with acute LVO of the anterior circulation who were treated at the Sir Run Run Shaw Hospital of Zhejiang Medical College from January 2018 to March 2021 were retrospectively analyzed. The patients were divided into NCCT-ASPECTS or CT perfusion groups. Baseline data, perioperative data, and 90-d prognostic information were compared between the two groups. Multivariable logistic regression analysis was used to determine the independent factors influencing outcomes.

Results: There were no significant differences in the good prognosis, symptomatic intracranial hemorrhage, and mortality rates between the two groups (P > 0.05). Multivariate logistic regression analysis showed that the puncture-recanalization time was an independent factor for good prognosis.

Conclusion: Based on NCCT-ASPECTS guidance, EVT in patients with WUS for acute LVO of the anterior circulation within 6 to 24 h may be safe and effective.

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NCCT-ASPECTS引导下血管内治疗醒脑大血管闭塞患者的临床疗效和安全性。

目的:评价非对比计算机断层扫描-阿尔伯塔卒中程序早期CT评分(NCCT-ASPECTS)引导下6 ~ 24 h血管内治疗(EVT)对伴有急性前循环大血管闭塞(LVO)的醒脑卒中(WUS)患者的临床疗效和安全性。方法:回顾性分析2018年1月至2021年3月浙江医学院邵逸夫医院收治的53例WUS合并急性前循环LVO患者。将患者分为NCCT-ASPECTS组和CT灌注组。比较两组患者的基线数据、围手术期数据和90 d预后信息。采用多变量logistic回归分析确定影响结果的独立因素。结果:两组患者预后、症状性颅内出血、病死率比较，差异均无统计学意义(P > 0.05)。多因素logistic回归分析显示，穿刺再通时间是影响预后的独立因素。结论:在NCCT-ASPECTS指导下，急性前循环LVO WUS患者在6 ~ 24 h内EVT可能是安全有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Interventional Neuroradiology CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

3.60

自引率

11.80%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Interventional Neuroradiology (INR) is a peer-reviewed clinical practice journal documenting the current state of interventional neuroradiology worldwide. INR publishes original clinical observations, descriptions of new techniques or procedures, case reports, and articles on the ethical and social aspects of related health care. Original research published in INR is related to the practice of interventional neuroradiology...