Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect.

Acta cirurgica brasileira Pub Date : 2023-12-01 eCollection Date: 2023-01-01 DOI:10.1590/acb385523

Yi Gong, Peipei Kang, Junhui Wang, Yan Chen, Zhongliang Wei

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Abstract

Purpose: Intravenous anesthetics have excellent analgesic activity without inducing the side effect in the respiratory system. The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats.

Methods: Isoflurane was used for induction the neurodysfunction in the rats, and rats received the oral administration of sevoflurane (2.5, 5 and 10 mg/kg). Morris water test was carried out for the estimation of cognitive function. Neurochemical parameters, antioxidant parameters and pro-inflammatory cytokines were also estimated.

Results: Sevoflurane significantly (P < 0.001) altered the neurochemical parameters such as anti-choline acetyltransferase, acetylcholine esterase, acetylcholine, protein carbonyl, choline brain-derived neurotrophic factor, and amyloid β; antioxidant parameters such as glutathione, superoxide dismutase, and malondialdehyde; pro-inflammatory cytokines include interleukin (IL-2, IL-10, IL-4, IL-6, IL-10, IL-1β), and tumor necrosis factor-α. Sevoflurane significantly reduced the activity of caspase-3.

Conclusions: Sevoflurane exhibited the neuroprotection against the cognitive dysfunction in rats via anti-inflammatory and antioxidant mechanism.

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七氟醚通过抗炎和抗氧化作用对异氟醚诱导的大鼠认知功能障碍的神经保护作用。

目的:静脉麻醉药具有良好的镇痛活性，对呼吸系统无不良反应。本实验旨在探讨七氟醚对异氟醚所致大鼠认知功能障碍的神经保护作用。方法:采用异氟醚诱导大鼠神经功能障碍，大鼠分别口服七氟醚(2.5、5、10 mg/kg)。采用Morris水试验估计认知功能。神经化学参数、抗氧化参数和促炎细胞因子也进行了评估。结果:七氟醚显著(P < 0.001)改变了大鼠抗胆碱乙酰转移酶、乙酰胆碱酯酶、乙酰胆碱、蛋白羰基、胆碱脑源性神经营养因子、β淀粉样蛋白等神经化学指标;抗氧化参数如谷胱甘肽、超氧化物歧化酶和丙二醛;促炎细胞因子包括白细胞介素(IL-2、IL-10、IL-4、IL-6、IL-10、IL-1β)和肿瘤坏死因子-α。七氟醚显著降低caspase-3活性。结论:七氟醚通过抗炎和抗氧化机制对大鼠认知功能障碍具有神经保护作用。

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Acta cirurgica brasileira

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