The pharmacological role of Ginsenoside Rg3 in liver diseases: A review on molecular mechanisms

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2023-11-15 DOI:10.1016/j.jgr.2023.11.004

Wenhong Wang , Ke Li , Weihua Xiao

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Abstract

Liver diseases are a significant global health burden and are among the most common diseases. Ginssennoside Rg3 (Rg3), which is one of the most abundant ginsenosides, has been found to have significant preventive and therapeutic effects against various types of diseases with minimal side effects. Numerous studies have demonstrated the significant preventive and therapeutic effects of Rg3 on various liver diseases such as viral hepatitis, acute liver injury, nonalcoholic liver diseases (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC). The underlying molecular mechanism behind these effects is attributed to apoptosis, autophagy, antioxidant, anti-inflammatory activities, and the regulation of multiple signaling pathways. This review provides a comprehensive description of the potential molecular mechanisms of Rg3 in the development of liver diseases. The article focuses on the regulation of apoptosis, oxidative stress, autophagy, inflammation, and other related factors. Additionally, the review discusses combination therapy and liver targeting strategy, which can accelerate the translation of Rg3 from bench to bedside. Overall, this article serves as a valuable reference for researchers and clinicians alike.

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人参皂苷Rg3在肝脏疾病中的药理作用及其分子机制研究进展

肝病是一项重大的全球健康负担，也是最常见的疾病之一。人参皂苷Rg3 (Ginssennoside Rg3)是含量最丰富的人参皂苷之一，对多种疾病具有显著的预防和治疗作用，且副作用极小。大量研究表明，Rg3对病毒性肝炎、急性肝损伤、非酒精性肝病(NAFLD)、肝纤维化和肝细胞癌(HCC)等多种肝脏疾病具有显著的预防和治疗作用。这些作用背后的潜在分子机制归因于细胞凋亡、自噬、抗氧化、抗炎活性和多种信号通路的调节。本文综述了Rg3在肝脏疾病发展中的潜在分子机制。本文重点介绍细胞凋亡、氧化应激、自噬、炎症等相关因素的调控。此外，本文还讨论了联合治疗和肝脏靶向策略，这可以加速Rg3从实验室到临床的转化。总之，本文为研究人员和临床医生提供了有价值的参考。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.