The Role and Application of Vesicles in Triple-negative Breast Cancer: Opportunities and Challenges

IF 5.3 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Molecular Therapy Oncolytics Pub Date : 2023-11-23 DOI:10.1016/j.omto.2023.100752
Ya-Nan Wei, Chun-Yan Yan, Meng-Lu Zhao, Xi-He Zhao
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Abstract

EVs (Extracellular vesicles) carry DNA, RNA, protein and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. TNBC (Triple-negative breast cancer) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the TME (tumor microenvironment) via EVs. In this article, we describe the roles of EVs in tumor immune microenvironment, metabolic microenvironment and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.

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囊泡在三阴性乳腺癌中的作用与应用:机遇与挑战
细胞外囊泡(Extracellular vesicles, EVs)携带DNA、RNA、蛋白质等参与细胞间串扰的物质,可用于靶向递送药物。TNBC(三阴性乳腺癌)是一种复发和转移性疾病,缺乏治疗靶点。研究证实了电动汽车在TNBC发生发展的不同阶段所起的作用。癌细胞积极分泌多种生物分子,这些生物分子在通过ev建立肿瘤微环境中起着重要作用。本文介绍了ev在肿瘤免疫微环境、代谢微环境和血管重构中的作用,并对ev在化疗药物、免疫抗原和肿瘤疫苗佐剂的客观递送中的应用进行了综述。基于ev的治疗可能代表下一代靶向药物递送工具,用于治疗缺乏有效药物治疗的各种疾病。
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来源期刊
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics Medicine-Oncology
CiteScore
10.90
自引率
3.50%
发文量
152
审稿时长
6 weeks
期刊介绍: Molecular Therapy — Oncolytics is an international, online-only, open access journal focusing on the development and clinical testing of viral, cellular, and other biological therapies targeting cancer.
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