{"title":"The Role and Application of Vesicles in Triple-negative Breast Cancer: Opportunities and Challenges","authors":"Ya-Nan Wei, Chun-Yan Yan, Meng-Lu Zhao, Xi-He Zhao","doi":"10.1016/j.omto.2023.100752","DOIUrl":null,"url":null,"abstract":"<p>EVs (Extracellular vesicles) carry DNA, RNA, protein and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. TNBC (Triple-negative breast cancer) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the TME (tumor microenvironment) via EVs. In this article, we describe the roles of EVs in tumor immune microenvironment, metabolic microenvironment and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.</p>","PeriodicalId":18869,"journal":{"name":"Molecular Therapy Oncolytics","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Therapy Oncolytics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.omto.2023.100752","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
EVs (Extracellular vesicles) carry DNA, RNA, protein and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. TNBC (Triple-negative breast cancer) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the TME (tumor microenvironment) via EVs. In this article, we describe the roles of EVs in tumor immune microenvironment, metabolic microenvironment and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.
期刊介绍：
Molecular Therapy — Oncolytics is an international, online-only, open access journal focusing on the development and clinical testing of viral, cellular, and other biological therapies targeting cancer.
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