Interleukin-3 gets a fresh start in the brain

IF 5 3区 医学 Q1 GENETICS & HEREDITY Genes and immunity Pub Date : 2023-12-08 DOI:10.1038/s41435-023-00231-w
Abi G. Yates, Annie Khamhoung, Cameron S. McAlpine
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白细胞介素-3在大脑中重获新生
神经系统和免疫系统深深地交织在一起。尽管我们知道这些系统之间的协调对健康的大脑至关重要,但在疾病中却会出现问题[1, 2],这种生物串扰的本质仍不清楚。我们最近的发现[3, 4]揭示了在神经炎症和神经变性过程中协调神经-免疫对话的新角色。通过使用多种小鼠模型和人体组织,我们发现白细胞介素-3(IL-3)是中枢神经系统和外周免疫系统之间的分子信使,它影响着脑部炎症,是一个新兴的治疗靶点。
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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
期刊最新文献
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