{"title":"Target search on DNA -- effect of coiling","authors":"Michael A. Lomholt, Ralf Metzler","doi":"arxiv-2312.05876","DOIUrl":null,"url":null,"abstract":"Some proteins can find their targets on DNA faster than by pure diffusion in\nthe 3-dimensional cytoplasm, through the process of facilitated diffusion: They\ncan loosely bind to DNA and temporarily slide along it, thus being guided by\nthe DNA molecule itself to the target. This chapter examines this process in\nmathematical detail with a focus on including the effect of DNA coiling on the\nsearch process.","PeriodicalId":501170,"journal":{"name":"arXiv - QuanBio - Subcellular Processes","volume":"2020 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Subcellular Processes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2312.05876","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Some proteins can find their targets on DNA faster than by pure diffusion in
the 3-dimensional cytoplasm, through the process of facilitated diffusion: They
can loosely bind to DNA and temporarily slide along it, thus being guided by
the DNA molecule itself to the target. This chapter examines this process in
mathematical detail with a focus on including the effect of DNA coiling on the
search process.
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