Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia

IF 1.6 Q3 HEMATOLOGY Hematology, Transfusion and Cell Therapy Pub Date : 2024-12-01 DOI:10.1016/j.htct.2023.10.003

Asmaa Abobakr , Randa A. Osman , Mohamed A.M. Kamal , Sayed Abdelhameed , Hagar Ismail , Mahmoud M. Kamel , Khalaf F. Alsharif , Nema R. Hamad

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Abstract

Introduction

The expression pattern of CD27 and CD44 was found to correlate with the differentiation stages of B cell precursors, which were known to be involved in a variety of immunological responses.

Aim of the study

This study aimed to determine the biological significance of CD27 and CD44 expression in patients with B-precursor acute lymphoblastic leukemia (B-ALL), as well as their association with standard prognostic factors and therapeutic response.

Patients and methods

This case-control study included 60 pediatric patients newly diagnosed with B-ALL and 30 pediatric controls. The patient CD27 and CD44 levels were measured using the Beckman Coulter Navios Flow Cytometer.

Results

Most malignant cells (91.6 %) expressed CD44, but only 50 % of the patients had CD27 expressed. The positive CD 44 expression was associated with unfavorable prognostic markers, including a decrease

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埃及儿科 B 前体急性淋巴细胞白血病患者 CD27 和 CD44 表达模式的临床和预后意义

CD27和CD44的表达模式被发现与B细胞前体的分化阶段相关，而B细胞前体参与了多种免疫反应。本研究旨在确定b前体急性淋巴细胞白血病（B-ALL）患者中CD27和CD44表达的生物学意义，以及它们与标准预后因素和治疗反应的关系。患者和方法本病例对照研究包括60例新诊断为B-ALL的儿童患者和30例儿童对照。使用Beckman Coulter Navios流式细胞仪检测患者CD27和CD44水平。结果大多数恶性肿瘤细胞（91.6%）表达CD44，而只有50%的患者表达CD27。cd44阳性表达与不利的预后标志物相关，包括减少

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