Looking to the future of antibody genetics: resolving the roles of immunoglobulin diversity in gene regulation, function, and immunity

IF 5 3区 医学 Q1 GENETICS & HEREDITY Genes and immunity Pub Date : 2023-12-14 DOI:10.1038/s41435-023-00238-3
Corey T. Watson, Oscar L. Rodriguez, Eric Engelbrecht, Yana Safonova, Wayne A. Marasco, Melissa L. Smith
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展望抗体遗传学的未来:解析免疫球蛋白多样性在基因调控、功能和免疫中的作用
在我们最近的文章[1]中,我们结合了人类免疫球蛋白重链(IGH)位点的靶向长读单分子实时(SMRT)测序和表达适应性免疫受体库测序(AIRR-seq),这些测序来自不同遗传血统的健康供者队列的血细胞。通过这些数据,我们揭示了IGH种系变异与循环抗体(Ab)库变异性之间的直接联系,确立了遗传因素在设定个体Ab反应基线中的基本作用。
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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
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