EFFECTIVENESS OF VISCOSUPPLEMENTATION IN THE TREATMENT OF HEMOPHILIC ARTHROPATHY: A SYSTEMATIC REVIEW.

IF 0.5 4区医学 Q4 ORTHOPEDICS Acta Ortopedica Brasileira Pub Date : 2023-12-18 eCollection Date: 2023-01-01 DOI:10.1590/1413-785220233105e271857

Samilly Conceição Maia Martins, Erion DE Andrade, Mayara Branco E Silva, Margareth Castro Ozelo, Gustavo Constantino DE Campos, Rodrigo Gonçalves Pagnano

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Abstract

Objective: To describe the efficacy of using viscosupplementation in patients with hemophilic arthropathy (HA), on pain, limb functionality, and quality of life.

Methods: A systematic review of the literature was performed following the PRISMA guidelines without limitations of language or year of publication. The search was performed on the following medical databases: PubMed, Cochrane Library, EMBASE, BVS/BIREME, Scopus, Web of Science, EBSCOhost, and PROQUEST in April 2020. The search used the following word: (hemophilia AND joint diseases) OR (haemophilic arthropathy OR hemophilic arthropathy) AND viscosupplementation.

Results: The systematic review identified 127 articles, 10 of which were selected for data extraction and qualitative analysis. The 10 selected articles included 297 joints with HA in 177 hemophilic subjects. Our review showed positive results in alleviating pain and improving functional capacity, and quality of life. No major adverse effects were observed.

Conclusion: There is a lack of scientific evidence regarding viscosupplementation with hyaluronic acid, but the results presented in this research suggest that it is an effective and safe therapeutic option to alleviate pain and improve functional capacity in patients with HA. Level of Evidence II, Systematic Review.

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治疗血友病关节病的粘液补充剂的有效性：系统性综述。

目的描述血友病关节病（HA）患者使用粘弹剂对疼痛、肢体功能和生活质量的疗效：按照 PRISMA 指南对文献进行了系统性回顾，没有语言或出版年份的限制。在以下医学数据库中进行了检索：PubMed、Cochrane Library、EMBASE、BVS/BIREME、Scopus、Web of Science、EBSCOhost 和 PROQUEST。检索使用了以下词：（血友病和关节疾病）或（血友病关节病或血友病关节病）和粘度补充剂：结果：系统综述发现了 127 篇文章，其中 10 篇被选中进行数据提取和定性分析。所选的 10 篇文章包括 177 名血友病受试者的 297 个患有 HA 的关节。我们的综述显示，在减轻疼痛、提高功能能力和生活质量方面取得了积极效果。没有观察到重大不良反应：关于用透明质酸补充粘度的科学证据尚缺，但本研究的结果表明，用透明质酸补充粘度是一种有效、安全的治疗方法，可减轻血友病患者的疼痛并改善其功能。证据等级 II，系统综述。

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来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.