TB impairs DNA repair.

IF 7.3 1区 生物学 Science Signaling Pub Date : 2023-12-19 DOI:10.1126/scisignal.adn5031
Annalisa M VanHook
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Abstract

A Mycobacterium tuberculosis virulence factor promotes foam cell formation by inhibiting DNA repair.

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结核病会损害 DNA 修复。
一种结核分枝杆菌毒力因子通过抑制 DNA 修复促进泡沫细胞的形成。
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来源期刊
Science Signaling
Science Signaling Biochemistry, Genetics and Molecular Biology-Molecular Biology
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发文量
148
期刊介绍: Science Signaling is a weekly, online multidisciplinary journal dedicated to the life sciences. Our editorial team's mission is to publish studies that elucidate the fundamental mechanisms underlying biological processes across various organisms. We prioritize research that offers novel insights into physiology, elucidates aberrant mechanisms leading to disease, identifies potential therapeutic targets and strategies, and characterizes the effects of drugs both in vitro and in vivo.
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A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling. Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses. RHOA drivers take alternate routes in gastric cancer. RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling. TB impairs DNA repair.
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